Laboratório: Experimental Vaccines Laboratory
Phone: 55 11 5576-4848 ext. 2319 and 2309
E-mail: [email protected] / [email protected]
Lattes CV: http://lattes.cnpq.br/1472798853821902
Development and evaluation of new HIV, Zika and Chikungunya virus vaccine candidates; effect of sleep deprivation on immunity
Infections caused by Human Immunodeficiency Virus (HIV), Zika (ZIKV) and Chikungunya (CHIKV) are a serious public health problem. Despite advances in the knowledge of the virus pathogenesis, there is no effective prophylactic vaccine against the infections caused by these viruses. Our research is aimed at identifying potential HIV, ZIKV and CHIKV target antigens, production of vaccine formulations and pre-clinical immunogenicity assessment studies.
We also focus our studies on the effect of REM sleep deprivation (Rapid Eye Movement) on immunity.
- Apostólico JS, Lunardelli VAS, Yamamoto MM, Souza HFS, Cunha-Neto E, Boscardin SB, Rosa DS . Dendritic cell targeting effectively boosts T cell responses elicited by an HIV multiepitope DNA vaccine. Frontiers in Immunology (Online), v.8, 2017.
- Cunha-Neto, E ; Rosa, DS ; Harris, P ; Olson, T ; Morrow, A ; Ciotlos, S ; Herst, C ; Rubsamen, R M . An approach for a synthetic CTL vaccine design against Zika flavivirus using class I and class II epitopes identified by computer modeling.. Frontiers in Immunology, v.9, p. 1, 2017.
- Apostólico JS, Lunnardelli VAS, Coirada FC, Boscardin SB, Rosa DS. Adjuvants: Classification, Modus Operandi and Licensing. J Immunol Res., v.2016, p.1 – 16, 2016.
- Apostólico JS, Boscardin SB, Yamamoto MM, de Oliveira-Filho JN, Kalil J, Cunha-Neto E, Rosa DS. HIV envelope trimer specific immune response is influenced by different adjuvant formulations and heterologous prime-boost. PLoS One, 2016 Jan 4;11(1):e0145637.