Nilmar Moretti, PhD

Adjuct Professor
Laboratory: Laboratory of Molecular Biology of Pathogens
Telefone: 55 11 5576-4870 x2928
E-mail: [email protected] / [email protected]
Lattes: http://lattes.cnpq.br/2131472726202687
Research ID: http://www.researcherid.com/rid/C-1864-2012
Google Academic: https://scholar.google.com/citations?user=Y016PesAAAAJ&hl=en
Research Gate: https://www.researchgate.net/profile/Nilmar_Moretti
ORCID: http://orcid.org/0000-0003-0455-2497

Research line

Role of protein acetylation in Trypanosomatids differentiation and infection

Information

Our research focuses on the mechanisms involved in the adaptation of Trypanosomatids in the distinct environments faced during their transitions from invertebrate to vertebrate hosts, with emphasis in the role of protein acetylation as primary regulator of diverse cellular processes. Protein acetylation is present in a variety of proteins in different cellular compartments and involved in distinctive functions and has been poorly explored in protozoan parasites. Using molecular biology, biochemistry and proteomics approaches we investigate how protein acetylation levels of non-histone proteins are regulates and which are the impact in parasite differentiation and infection. Another aspect of our research is focused in the effect of Trypanosoma cruzi and Leishmania sp. infection in protein acetylation of key enzymes responsible to regulate host cell metabolism and inflammatory response. All these aspects are important to better understand the biology of these important parasites and open the opportunity to explore the enzymes responsible for protein acetylation as drug targets.

Recent publications

1. Anna Cláudia Guimarães Freire, Ceres Luciana Alves, Grazielle Ribeiro Goes1, Bruno Carvalho Resende, Nilmar Silvio Moretti, Vinícius Santana Nunes, Pedro Henrique Nascimento Aguiar, Erich Birelli Tahara, Glória Regina Franco, Andréa Mara Macedo, Sérgio Danilo Junho Pena, Fernanda Ramos Gadelha, Alessandra Aparecida Guarneri, Sergio Schenkman, Leda Quercia Vieira, Carlos Renato Machado. “Catalase expression impairs oxidative stress-mediated signaling in Trypanosoma cruzi”. Parasitology. 2017.
2. Calderano, Simone Guedes; Moretti, Nilmar Silvio; Araujo, Christiane; da Silva, Marcelo S.; de Jesus, Teresa Cristina Leandro; de Lima, Loyze P. Oliveira; Lopes, Mariana de Camargo; Augusto, Leonardo da Silva; da Cunha, Julia Pinheiro Chagas; Elias, Maria Carolina; Schenkman, Sergio. “The Cellular Organization of Trypanosomatids During Life Cycle”. In book: Frontiers in Parasitology: Molecular and Cellular Biology of Pathogenic Trypanosomatids. v1, p. 3-60. 2017
3. Nunes, Vinicius Santana and Moretti, Nilmar Silvio. “Nuclear subcompartments: an overview”. Cell Biology International. v 41, p. 2-7, 2017.
4. De Jesus, Teresa Cristina Leandro; Nunes, Vinicius Santana; Lopes, Mariana de Camargo; Martil, Daiana Evelin; Iwai, Leo Kei; Moretti, Nilmar Silvio; Machado, Fabricio Castro; De Lima-Stein, Mariana l; Thiemann, Otavio Henrique; Elias, Maria Carolina; Janzen, Christian J.; Schenkman, Sergio; Da Cunha, Julia PC. Chromatin proteomics reveals variable histone modifications during the life cycle of Trypanosoma cruzi. Journal of Proteome Research (Print), v. 15, p. 1-13, 2016.
5. Cestari, Igor; Haas, Paige; Moretti, Nilmar Silvio; Schenkman, Sergio; Stuart, Ken. Chemogenetic Characterization of Inositol Phosphate Metabolic Pathway Reveals Druggable Enzymes for Targeting Kinetoplastid Parasites. Cell Chemical Biology, v. 23, p. 608-617, 2016.
6. Ramos, Thiago Cesar Prata; Nunes, Vinicius Santana; Nardelli, Sheila Cristina; Pascoalino, Bruno dos Santos; Moretti, Nilmar Silvio; Rocha, Antonio Augusto; Augusto, Leonardo da Silva; Schenkman, Sergio. Expression of non-acetylatable lysines 10 and 14 of histone H4 impairs transcription and replication in Trypanosoma cruzi. Molecular and Biochemical Parasitology (Print), v. 204, p. 1-10, 2015.
7. Moretti, Nilmar Silvio, Da Silva Augusto, Leonardo, Clemente, Tatiana Mordente, Antunes, Raysa Pinto, Yoshida, Nobuko, Torrecilhas, Ana Claudia, Cano, Maria Isabel, Schenkman, Sergio. “Characterization of Trypanosoma cruzi sirtuins as possible drug targets for Chagas disease”. Antimicrobial Agents and Chemotherapy. v. 59, p. AAC.04694-14, 2015.
8. Da Silva Augusto, Leonardo, Moretti, Nilmar Silvio, Ramos, Thiago Cesar Prata, de Jesus, Teresa Cristina Leandro, Zhang, Min, Castilho, Beatriz A., Schenkman, Sergio. “A membrane-bound eif2 alpha kinase located in endosomes is regulated by heme and controls differentiation and ROS levels in Trypanosoma cruzi”. Plos Pathogens (online). , v.11, p.e1004618 – , 2015
9. Phan, Isabelle Q. H., Davies, Douglas R., Moretti, Nilmar Silvio, Shanmugam, Dhanasekaran, Cestari, Igor, Anupama, Atashi, Fairman, James W., Edwards, Thomas e., Stuart, Kenneth, Schenkman, Sergio, Myler, Peter J. “Iron superoxide dismutases in eukaryotic pathogens: new insights from apicomplexa and structures”. Acta Crystallographica Section F Structural Biology Communications. , v.71, p.615 – 621, 2015.
10. Rocha, A. A., Moretti, N. S., Schenkman, S. “Stress induces changes in the phosphorylation of Trypanosoma cruzi RNA polymerase II, affecting its association with chromatin and RNA processing”. Eukaryotic Cell (online). , v.13, p.855 – 865, 2014.
11. Moretti, Nilmar Silvio, Schenkman, Sergio. “Chromatin modifications in trypanosomes due to stress”. Cellular Microbiology (print)., v.15, p.n/a – n/a, 2013.