Title: Adjunct Professor
Laboratory: Laboratory of cell signaling and gene expression in parasites
Phone: 55 11 5576-4848 ext. 2924 and 2925
E-mail: [email protected]
Lattes CV: http://lattes.cnpq.br/4758763489087525
Study of signaling pathways and their role in gene expression regulation in Schistosoma mansoni. (www.schistosig.com)
Schistosomiasis is a serious public health problem in Brazil and in developing countries. It is caused by the parasite Schistosoma mansoni that has a complex life cycle involving an intermediate host (mollusk) and a definitive host (man) . The interaction between the parasite and the hosts has been a constant target of study, highlighting the signaling elements as key factors for the understanding of this interaction. Several human cytokines exert an effect on the parasite, for example TNF-α. The description of the homologous TNF-α receptor gene in S. mansoni (SmTNFR) and the identification of homologous genes from its possible signaling pathway has been the subject of investigation by our research group. We aim to understand the effect of human TNF-α on the parasite, characterize the cell signaling pathway and study the modulations in gene expression induced by this molecular dialogue between the parasite and the host.
- Oliveira, K. C. , Carvalho, Mariana L. P. , Bonatto, José Matheus C. , Schechtman, Debora , Verjovski-Almeida, S. . Human TNF-α induces differential protein phosphorylation in Schistosoma mansoni adult male worms. Parasitology Research (1987. Print), Artigo Publicado – JCR v. 115, p. 817-828, n. 2016.
- Oliveira, K. C. , Carvalho, M. L. P. , Carvalho, Mariana L.P. , Verjovski-Almeida, Sergio , LoVerde, Philip T. . Effect of human TGF- on the gene expression profile of Schistosoma mansoni adult worms. Molecular and Biochemical Parasitology (Print), Artigo Publicado – JCR v. 183, p. 132-139, n. 2012.
- Oliveira, K. C. , Carvalho, Mariana L. P. , Maracaja-Coutinho, V. , KITAJIMA, J. P. , Verjovski-Almeida, S. , Verjovski-Almeida, S. . Non-coding RNAs in schistosomes: an unexplored world. Anais da Academia Brasileira de Ciências (Impresso), Artigo Publicado – JCR v. 83, p. 673-694, n. 2011.
- OLIVEIRA, KATIA C. ; Carvalho, Mariana L. P. ; Venancio, Thiago M. ; Miyasato, Patricia A. ; Kawano, Toshie ; DeMarco, Ricardo ; Verjovski-Almeida, Sergio . Identification of the Schistosoma mansoni TNF-Alpha Receptor Gene and the Effect of Human TNF-Alpha on the Parasite Gene Expression Profile. Plos Neglected Tropical Diseases, v. 3, p. e556, 2009.